Carbohydrate antigen 19-9 (CA19-9)

CA19-9 Antibody

Name	Anti-Human Carbohydrate antigen 19-9 (CA19-9) antibody
Catalog #	R272n2	R205t6	R188c1
Platforms Usage	Chemiluminescence immunoassay (CLIA)
	R272n2 (Capture)-R205t6 (Detection) R188c1 (Capture)-R205t6 (Detection)
Description	Mouse monoclonal antibody, cultured in vitro
Buffer	1xPBS，pH 7.4
Purity	Purity>95%, purified by Protein A/G chromatography
Storage	Aliquot and store at -20°C or lower. Avoid freeze / thaw cycles.

CA19-9 Antibody Conjugates

CA19-9 Antibody Conjugated Magnetic Beads

Name	Catalog#
CA 19-9 antibody conjugated magnetic beads	B310e1
	B311e1
	B312e1

Labeled CA19-9 Antibody

Name	Catalog #
Biotin labeled CA19-9 antibody	L323f1
Acridinium ester (AE) labeled CA19-9 antibody	L320f1
Alkaline phosphatase (ALP) labeled CA19-9 antibody	L322f1

Product Information

Alkaline phosphatase-labeled Chemiluminescence (ALP-CLIA) platform

Correlation in clinical samples
R272n2-R205t6 matched antibody pair was verified in Roche^TM serum assigned samples (39 cases, concentration:1.18-919.2U/mL, clinical coefficient of determination R² > 0.93).

Sample No.	Concentration （U/mL）	Concentration of Detection （U/mL）
1	1.18	0.252
2	2.48	2.02
3	3.58	4.24
...	...	...
38	890.0	917.5
39	919.2	812.3

Fig.1 Correlation of CA19-9 on CLIA platform in clinical samples

Table.1 Correlation data in clinical samples

Introduction to Carbohydrate antigen 19-9 (CA19-9)

Biological functions of carbohydrate antigen 19-9 (CA19-9)

Carbohydrate antigen 19-9 (CA19-9) is a mucin-type carbohydrate protein indicator for tumor, which is a glycolipid on the cell membrane and is generally formed from Lewis antigens (including Le-a and Le-b ) precursors under the joint action of sialyltransferase and fucosyltransferase. CA19-9 is distributed in epithelial cells of pancreas and bile duct of normal human. CA19-9 also exists in the form of salivary mucin in serum, but the content is very low. Studies have shown that CA19-9 can trigger the development of pancreatitis by accelerating the excessive activation of pancreatic epidermal growth factor receptor (EGFR) signaling, leading to the progression of pancreatitis to pancreatic cancer.

Significance of clinical diagnosis

CA19-9 is often applied in the clinical diagnosis of pancreatic cancer and is also used in the clinical auxiliary detection of gastric cancer, colorectal cancer, gallbladder cancer, bile duct cancer and liver cancer. After tumor resection, the concentration of CA19-9 will decrease. If it rises, it may indicate tumor recurrence. However, it should be noted that CA19-9 will also increase under the influence of many benign diseases, and it is difficult to apply it to the screening and early diagnosis of malignant tumors. Therefore, it needs to be detected combined with other indicators, such as: combined detection of CA19-9, CA125, AFP, CEA and HE4 in the diagnosis of ovarian cancer; combined detection of CA19-9, SCCA, CYFRA21-1, and NSE levels in the diagnosis and treatment of non-small cell lung cancer; combined detection of CA19-9, β2-MG and PSA in the diagnosis of prostate cancer; combined ultrasound detection of serum CA19-9 and CA15-3 in the diagnosis of breast cancer.